Skip to main content
SpringerLink
Log in

Comparative Dissolution Kinetics of Ibuprofen 200-Mg Capsules (Medisorb Co., Russia) and Ibuprofen 200-Mg Coated Tablets (Biosynthesis Co., Russia)

  • STRUCTURE OF CHEMICAL COMPOUNDS, METHODS OF ANALYSIS AND PROCESS CONTROL
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Experimental data on the comparative dissolution kinetics of two ibuprofen preparations from different manufacturers are presented. The study was performed in three buffer solutions at pH 1.2, 4.5, and 6.8 according to requirements of the Scientific Center for Expert Evaluation of Medicinal Products of the Russian Federation. A fourth dissolution medium was buffer solution at pH 7.2, which is included in a draft regulation. The test used a Erweka DT-720 rotating-basket device.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

References

  1. O. Yu. Baula, Current Regulatory Requirements for Research and Registration of Generic Drugs [in Russian], Farmsodruzhestvo, Moscow (2007).

    Google Scholar 

  2. Directive 2004 / 27 / EC of the European Parliament and of the Council, Art. 10.1 (2004).

  3. A. I. Tentsova and I. S. Azhgikhin, Dosage Form and Therapeutic Efficacy of Drugs. (Introduction to Biopharmacy) [in Russian], Meditsina, Moscow (1974), pp. 57 – 58.

    Google Scholar 

  4. V. G. Kukes and V. P. Fisenko (eds.), Bioequivalence Assessment of Drugs. Methodical Instructions [in Russian], Ministry of Health and Social Development (MHSD) of the RF, Moscow (2008).

    Google Scholar 

  5. A. N. Mironov (ed.), Guide for Drug Review [in Russian], Vol. 3, Poligraf-plyus, Moscow (2014), p. 218.

    Google Scholar 

  6. V. Shah, Y. Tsong, P. Sathe, and R. Williams, Dissolution Profile Comparison Using Similarity Factor f 2, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), FDA (2004).

  7. Guidance for Industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms (1997).

Download references

Author information

Authors and Affiliations

  1. E. A. Wagner Perm State Medical University, 26 Petropavlovskaya St., Perm, 614000, Russia

    N. A. Prozorova & G. P. Vdovina

  2. Medisorb Co., 6 Gal’perina St., Perm, 614113, Russia

    N. A. Prozorova & A. V. Bobrov

Authors
  1. N. A. Prozorova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. P. Vdovina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Bobrov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. A. Prozorova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 50 – 53, March, 2018.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Prozorova, N.A., Vdovina, G.P. & Bobrov, A.V. Comparative Dissolution Kinetics of Ibuprofen 200-Mg Capsules (Medisorb Co., Russia) and Ibuprofen 200-Mg Coated Tablets (Biosynthesis Co., Russia). Pharm Chem J 52, 245–247 (2018). https://doi.org/10.1007/s11094-018-1800-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-018-1800-y

Keywords

Search

Navigation