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Solubility and Stability of Proroxan at Various PH Values

Pharmaceutical Chemistry Journal volume 52, pages 236–240 (2018)Cite this article

The solubility and stability of the nonselective α-adrenoblocker 1-(2,3-dihydro-1,4-benzdioxin-6-yl)-3-(3-phenyl-1-pyrrolidinyl)-1-propanone hydrochloride (proroxan) at various pH values were investigated. It was established that proroxan solubility was reduced for 3 < pH < 5.5, which corresponded to the protonated species; was uncharacteristic for salts of organic bases; and increased its destruction. It was suggested that this peculiarity of proroxan behavior in aqueous solutions could reflect complexation between its protonated and unprotonated molecules. The results indicated that proroxan preparations using dosage forms and delivery systems that provide its maximum absorption in the stomach must be developed.

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Acknowledgments

The work was financially supported by the RF Ministry of Education and Science (Contract No. 02.G25.31.0001) under RF Government Decree No. 218 dated Apr. 9, 2010.

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Authors and Affiliations

  1. Department of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), Dolgoprudnyi, Moscow Region, 141700, Russia

    S. P. Krechetov, G. O. Nifontova, O. V. Dolotova & M. S. Veselov

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  1. S. P. Krechetov
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  2. G. O. Nifontova
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  3. O. V. Dolotova
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  4. M. S. Veselov
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Correspondence to S. P. Krechetov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 41 – 45, March, 2018.

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Krechetov, S.P., Nifontova, G.O., Dolotova, O.V. et al. Solubility and Stability of Proroxan at Various PH Values. Pharm Chem J 52, 236–240 (2018). https://doi.org/10.1007/s11094-018-1798-1

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  • DOI: https://doi.org/10.1007/s11094-018-1798-1

Keywords

  • proroxan
  • solubility
  • stability
  • pH