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Glucokinase Activators Based on N-Aryl-N′-Pyridin-2-Ylurea Derivatives

A series of previously undescribed N-aryl-N′-pyridin-2-ylureas were prepared via the reaction of 2-aminopyridines with benzoyl azides and tested in vitro as activators of glucokinase. Statistically significant reductions of glucose levels as compared with controls were demonstrated for several compounds.

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Correspondence to A. V. Semenov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 21 – 24, March, 2018.

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Semenov, A.V., Tarasova, I.V., Khramov, V.S. et al. Glucokinase Activators Based on N-Aryl-N′-Pyridin-2-Ylurea Derivatives. Pharm Chem J 52, 209–212 (2018). https://doi.org/10.1007/s11094-018-1792-7

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  • DOI: https://doi.org/10.1007/s11094-018-1792-7

Keywords

  • glucokinase activators
  • N-aryl-N -pyridin-2-ylurea