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Effect of N-[Imino(1-Piperidinyl)Methyl]Guanidine on Free-Radical Processes and Antioxidant-Enzyme Activity in Kidneys of Rats with Experimental Type 2 Diabetes Mellitus

The effect of the synthetic biguanide derivative N-[imino(1-piperidinyl)methyl]guanidine on free-radical processes, diene conjugate levels, and superoxide-dismutase and catalase activity in kidneys of rats with experimental type 2 diabetes mellitus (DM2) was studied. It was established that administration of this compound to rats with DM2 helped to normalize the studied parameters, which may have been due to its positive regulating effect on free-radical homeostasis.

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Correspondence to E. I. Sklyarova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 3, pp. 3 – 6, March, 2018.

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Sklyarova, E.I., Popova, T.N., Shul’gin, K.K. et al. Effect of N-[Imino(1-Piperidinyl)Methyl]Guanidine on Free-Radical Processes and Antioxidant-Enzyme Activity in Kidneys of Rats with Experimental Type 2 Diabetes Mellitus. Pharm Chem J 52, 191–194 (2018). https://doi.org/10.1007/s11094-018-1788-3

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  • DOI: https://doi.org/10.1007/s11094-018-1788-3

Keywords

  • type 2 diabetes mellitus
  • free-radical processes
  • antioxidant enzymes
  • biguanides