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Selective Voltammetric Determination of Sulfur-Containing Amino Acids in Drugs and Vitamin Complexes on an Electrode Modified by a Ruthenium-Hexachloroplatinate Film

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An inorganic film of ruthenium hexachloroplatinate (RuPtCl6) deposited on the surface of a glassy-carbon electrode exhibited catalytic activity for oxidation of S-containing amino acids. Catalytic electrochemical oxidation of cysteine, cystine, and methionine occurred at various potentials. The optimum conditions for producing a RuPtCl6 film that gave the greatest catalytic effect were found. A method for selective voltammetric determination of cysteine, methionine, and cystine at an RuPtCl6-film electrode was developed. The lower limit of quantitation of cysteine and cystine was 5 × 10–6 M; of methionine, 5 × 10–7 M. The proposed voltammetric method was used to determine cysteine, cystine, and methionine in drugs and vitamin complexes.

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Acknowledgments

The work was sponsored by a subsidy for state support of Kazan (Volga-region) Federal University for the purpose of increasing its competitiveness among leading global scientific research centers.

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Authors and Affiliations

  1. A. M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya St., Kazan, Tatarstan, 420008, Russia

    L. G. Shaidarova, A. V. Gedmina, É. R. Zhaldak, I. A. Chelnokova, V. D. Demina & G. K. Budnikov

Authors
  1. L. G. Shaidarova
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  2. A. V. Gedmina
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  3. É. R. Zhaldak
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  4. I. A. Chelnokova
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  5. V. D. Demina
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  6. G. K. Budnikov
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Corresponding author

Correspondence to L. G. Shaidarova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 2, pp. 34 – 39, February, 2018.

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Shaidarova, L.G., Gedmina, A.V., Zhaldak, É.R. et al. Selective Voltammetric Determination of Sulfur-Containing Amino Acids in Drugs and Vitamin Complexes on an Electrode Modified by a Ruthenium-Hexachloroplatinate Film. Pharm Chem J 52, 145–150 (2018). https://doi.org/10.1007/s11094-018-1780-y

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  • DOI: https://doi.org/10.1007/s11094-018-1780-y

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