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Hydrogel Nanoparticles of Chitosan—Folic-Acid Conjugate with Imatinib Methanesulfonate

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Hydrogel particles containing up to 49 mass% imatinib methanesulfonate (mesylate) (IM) were prepared from the chitosan—folic-acid conjugate. The release kinetics of IM from the particles in solutions simulating physiological body media were studied. It was established that the release kinetics of IM from the chitosan—folic-acid conjugate particles obeyed the Korsmeyer—Peppas model and a reciprocal power function of time. It was shown that the release rate of IM from the hydrogel particles could be controlled by varying the folic-acid content in the conjugate.

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Authors and Affiliations

  1. Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    M. É. Lozovskaya, V. I. Kulikovskaya, Zh. V. Ignatovich, E. V. Koroleva & V. E. Agabekov

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  1. M. É. Lozovskaya
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  2. V. I. Kulikovskaya
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  3. Zh. V. Ignatovich
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  4. E. V. Koroleva
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  5. V. E. Agabekov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 2, pp. 22 – 27, February, 2018.

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Lozovskaya, M.É., Kulikovskaya, V.I., Ignatovich, Z.V. et al. Hydrogel Nanoparticles of Chitosan—Folic-Acid Conjugate with Imatinib Methanesulfonate. Pharm Chem J 52, 127–132 (2018). https://doi.org/10.1007/s11094-018-1777-6

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  • DOI: https://doi.org/10.1007/s11094-018-1777-6

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