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Preparation of Low-Molecular-Weight Heparins by Radiation-Induced Destruction

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Low-molecular-weight heparins (LMWHs) are widely used in medical practice. LMWHs are produced using various methods of controlled depolymerization of unfractionated heparin (UFH). Herein, a method for radiation-induced destruction of aqueous heparin solutions using a 60Co gamma-irradiation source is presented. The optimal conditions for depolymerization of starting heparin were found. The anticoagulant activity of LMWHs was studied as a function of irradiation dose. The results allowed this LMWH production method to be recommended for development of new anticoagulants.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    N. O. Tuaeva, V. M. Trukhan, D. A. Kardonskii, A. A. Eganov, E. V. Grebenkina & V. V. Veselov

  2. Kazan State Medical Academy, Branch of the Russian Medical Academy for Continuing Professional Education, Ministry of Health of the Russian Federation, Kazan, Tatarstan, 420012, Russia

    N. O. Tuaeva

Authors
  1. N. O. Tuaeva
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  2. V. M. Trukhan
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  3. D. A. Kardonskii
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  4. A. A. Eganov
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  5. E. V. Grebenkina
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  6. V. V. Veselov
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Corresponding author

Correspondence to N. O. Tuaeva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 2, pp. 17 – 21, February, 2018.

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Tuaeva, N.O., Trukhan, V.M., Kardonskii, D.A. et al. Preparation of Low-Molecular-Weight Heparins by Radiation-Induced Destruction. Pharm Chem J 52, 122–126 (2018). https://doi.org/10.1007/s11094-018-1776-7

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  • DOI: https://doi.org/10.1007/s11094-018-1776-7

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