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Synthesis and Neurotropic Activity of New 7-Cyclohexyl-6,7,8,9-Tetrahydro-3H-Pyrazolo[3,4-c]-2,7-Naphthyridine-1,5-Diamines

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A method for synthesizing new tricyclic heterocyclic 7-cyclohexyl-6,7,8,9-tetrahydro-3H-pyrazolo- [3,4-c]-2,7-naphthyridine-1,5-diamines from 1,3-dichloro-7-cyclohexyl-5,6, 7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile was elaborated. Investigation of the biological activity of the synthesized compounds showed that several of them exhibited pronounced neurotropic properties.

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Acknowledgments

The work was financially supported by the State Committee for Science of the Ministry of Education and Science of the Republic of Armenia under Science Project No. 15T-1D221.

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Authors and Affiliations

  1. A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Prosp. Azatutyan, 0014, 375014, Yerevan, Armenia

    S. N. Sirakanyan, E. K. Hakobyan, A. G. Nikoghosyan, R. G. Paronikyan, I. A. Dzhagatspanyan, I. M. Nazaryan, A. G. Akopyan & A. A. Hovakimyan

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  1. S. N. Sirakanyan
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  2. E. K. Hakobyan
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  3. A. G. Nikoghosyan
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  4. R. G. Paronikyan
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  5. I. A. Dzhagatspanyan
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  6. I. M. Nazaryan
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  7. A. G. Akopyan
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  8. A. A. Hovakimyan
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Correspondence to S. N. Sirakanyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 2, pp. 8 – 11, February, 2018.

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Sirakanyan, S.N., Hakobyan, E.K., Nikoghosyan, A.G. et al. Synthesis and Neurotropic Activity of New 7-Cyclohexyl-6,7,8,9-Tetrahydro-3H-Pyrazolo[3,4-c]-2,7-Naphthyridine-1,5-Diamines. Pharm Chem J 52, 108–111 (2018). https://doi.org/10.1007/s11094-018-1773-x

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  • DOI: https://doi.org/10.1007/s11094-018-1773-x

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