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Pharmaceutical Chemistry Journal

, Volume 52, Issue 1, pp 1–7 | Cite as

Solvent-Free Synthesis and Antibacterial Evaluation of Novel Coumarin Sulfonamides

  • Neda Mostajeran
  • Farzaneh Amin Arshad
  • Hamid Aliyan
  • Ahmad Reza Massah
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A series of new coumarin-6-sulfonamides have been synthesized as potential antibacterial agents. The reaction of coumarin with chlorosulfonic acid was found to yield the corresponding coumarin sulfonyl chloride (1). In the next step, coumarin sulfonyl chloride, was reacted with various amines in the presence of K2CO3 under solvent-free conditions to produce coumarine sulfonamides (2a – 2s) in good to excellent yields. The chemical structures of the products were elucidated by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. All the synthesized compounds have been screened for their in vitro anti-bacterial activities against Escherichia coli and Staphylococcus aureus bacteria.

Keywords

coumarin sulfonamide solvent-free synthesis antibacterial 

Notes

Acknowledgments

The aujthors appreciate financial support from Research Council of the Shahreza Branch, Islamic Azad University (IAUSH).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Neda Mostajeran
    • 1
  • Farzaneh Amin Arshad
    • 1
  • Hamid Aliyan
    • 1
    • 2
  • Ahmad Reza Massah
    • 1
    • 2
  1. 1.Department of Chemistry, Shahreza BranchIslamic Azad UniversityShahrezaIran
  2. 2.Razi Chemistry Research Center, Shahreza BranchIslamic Azad UniversityShahrezaIran

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