A method for simultaneous determination of metoprolol and bisoprolol in human blood serum by HPLC-MS/MS was developed and validated. The analytical ranges of the method were 5 – 250 ng/mL and 1 – 250 ng/mL for metoprolol and bisoprolol, respectively. The suitability of the developed for therapeutic drug monitoring during treatment for arterial hypertension and other cardiovascular diseases was demonstrated. In particular, the proposed method could identify patients at high risk for developing adverse effects and help to monitor a switch between metoprolol and bisoprolol while changing the pharmacotherapy regime.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 12, pp. 39 – 46, December, 2017.
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Rodina, T.A., Mel’nikov, E.S., Dmitriev, A.I. et al. Simultaneous Determination of Metoprolol and Bisoprolol in Human Serum by HPLC-MS/MS for Clinical Drug Monitoring. Pharm Chem J 51, 1111–1118 (2018). https://doi.org/10.1007/s11094-018-1750-4
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DOI: https://doi.org/10.1007/s11094-018-1750-4