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Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma

  • STRUCTURE OF CHEMICAL COMPOUNDS, METHODS OF ANALYSIS AND PROCESS CONTROL
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Pharmaceutical Chemistry Journal Aims and scope

A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 – 2 μg/mL. The method could be used for pharmacokinetic studies.

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Acknowledgments

The work was sponsored by RSF Grant 15-13-17.

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090, Russia

    A. S. Sokolova, O. I. Yarovaya, A. A. Nefedov & N. F. Salakhutdinov

  2. Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia

    A. S. Sokolova, O. I. Yarovaya, A. A. Nefedov & N. F. Salakhutdinov

Authors
  1. A. S. Sokolova
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  2. O. I. Yarovaya
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  3. A. A. Nefedov
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  4. N. F. Salakhutdinov
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Corresponding author

Correspondence to A. S. Sokolova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 12, pp. 30 – 33, December, 2017.

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Sokolova, A.S., Yarovaya, O.I., Nefedov, A.A. et al. Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma. Pharm Chem J 51, 1102–1105 (2018). https://doi.org/10.1007/s11094-018-1748-y

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  • DOI: https://doi.org/10.1007/s11094-018-1748-y

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