Skip to main content

Advertisement

SpringerLink
Log in

Anti-Candida Activity of 4-Morpholino-5-Nitro- and 4,5-Dinitro-Imidazole Derivatives

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

The activities of some 4-morpholino-5-nitro- and 4,5-dinitro-imidazole derivatives with respect to several Candida species were evaluated. It is established that 4,5-dinitroimidazole derivatives constitute an important group of compounds possessing antifungal activity against Candida species. Some analogs showed moderate antifungal ability in vitro, especially in relation well-known antifungals such as flucytosine (5FC). The best results of antifungal action were obtained for 1-(3-bromo-2-hydroxypropyl)-2-methyl-4,5-dinitroimidazole (3c), 1-(3-bromo-2-oxopropyl)-2-methyl-4,5-dinitroimidazole (4c) and 2-methyl-1-phenacyl-4,5-dinitroimidazole (2b). The latter compound proved to be effective against Candida sake S-1 (in contrast to inactive 5FC).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1.

Similar content being viewed by others

References

  1. J. H. Meurman, E. Siikala, M. Richardson, et al., in: Communicating Current Research and Educational Topics and Trends in Applied Microbiology, Microbiology Book Series, A. Méndez-Vilas (ed.), Badajoz, Formatex 1 (2007), pp. 719 – 731.

  2. L. De Luca, Curr. Med. Chem., 13, 1 – 23 (2006).

    PubMed  Google Scholar 

  3. E. R. Dabbs, S. Naidoo, C. Lephoto, et al, Antimicrob. Agents Chemother., 47, 1476 – 1478 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. D. Olender, J. Żwawiak, V. Lukianchuk, et al., Eur. J. Med. Chem., 44, 645 – 652 (2009).

    Article  CAS  PubMed  Google Scholar 

  5. A. Casalinuovo, P. Di Francesco, and E. Garaci, Eur. Rev. Med. Pharmacol. Sci., 8, 69 – 77 (2004).

    CAS  PubMed  Google Scholar 

  6. L. Zaprutko, U. Wrzeciono, M. Gajdziñski, et al., Pharmazie, 47, 258 – 261 (1992).

    CAS  PubMed  Google Scholar 

  7. L. Zaprutko, M. Gajdziński, W. Michalska, et al., Pharmazie, 44, 817 – 820 (1989).

    CAS  PubMed  Google Scholar 

  8. D. Olender, J. Żwawiak, and L. Zaprutko, J. Heterocycl. Chem., 47, 1049 – 1055 (2010).

    Article  CAS  Google Scholar 

  9. J. Żwawiak, D. Olender, Z. Zwolska, et al., Acta Polon. Pharm.-Drug Res., 2, 229 – 233 (2008).

    Google Scholar 

  10. L. Zaprutko, D. Olender, and A. Gzella, Monatsch. Chem., 134, 1145 – 1150 (2003).

    Article  CAS  Google Scholar 

  11. W. Bauer, W. M. M. Kirby, J. C. Sherris, et al., Am. J. Clin. Pathol., 36, 493 – 496 (1966).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60 – 780, Poznań, Poland

    Dorota Olender & Lucjusz Zaprutko

  2. Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41 – 808, Zabrze, Poland

    Anna Mertas, Ewelina Szliszka, Dariusz Wyrozumski & Wojciech Król

Authors
  1. Dorota Olender
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lucjusz Zaprutko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anna Mertas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ewelina Szliszka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dariusz Wyrozumski
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wojciech Król
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dorota Olender.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Olender, D., Zaprutko, L., Mertas, A. et al. Anti-Candida Activity of 4-Morpholino-5-Nitro- and 4,5-Dinitro-Imidazole Derivatives. Pharm Chem J 51, 1063–1067 (2018). https://doi.org/10.1007/s11094-018-1741-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-018-1741-5

Keywords

Search

Navigation