A synthetic method for 7,10-dimethyl-2-thioxo-2,3-dihydro-1H-spiro[benzo[h]quinazoline-5,1′-cyclopentane]- 4(6H)-one from ethyl 4′-amino-5′,8′-dimethyl-1′-H-spiro[cyclopentane-1,2′-naphthalene]-3′-carboxylate was developed. Reaction of the spirobenzo[h]quinazoline with various alkyl(benzyl) halides synthesized a novel series of spirobenzo[h]quinazolines containing methyl substituents on the benzene ring. The antidepressant, anticonvulsant, and antibacterial activities of the synthesized spirobenzo[h]quinazolines were investigated.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 12, pp. 11 – 16, December, 2017.
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Grigoryan, N.P., Markosyan, A.I., Grigoryan, A.S. et al. Synthesis and Biological Activity of 2-Mercapto-7,10-Dimethyl-3H-Spiro[Benzo[H]Quinazoline-5,1′-Cyclopentane]-4(6H)-One from Ethyl 4′-Amino-5′,8′-Dimethyl-1′H-Spiro[Cyclopentane-1,2′-Naphthalene]-3′-Carboxylate. Pharm Chem J 51, 1057–1062 (2018). https://doi.org/10.1007/s11094-018-1740-6
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DOI: https://doi.org/10.1007/s11094-018-1740-6