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Pharmaceutical Chemistry Journal

, Volume 51, Issue 12, pp 1053–1056 | Cite as

Hemostasis Parameters and Toxic Effects of 3-Substituted and Condensed Chromen-2-Ones (Coumarins)

  • D. N. Ibragimova
  • O. V. Fedotova
  • A. G. Ozerova
  • O. V. Koftin
  • V. B. Borodulin
  • V. A. Samokhvalov
Article

Biochemical investigations of 3-substituted chromen-2-ones (coumarins) and those condensed with biologically active azaheterocycles assessed their toxic effects and influence on the blood-coagulation system. The studied group of compounds behaved in the initial time period like the well-known anticoagulant warfarin and exhibited insignificant toxic effects.

Keywords

chromen-2-ones Mannich bases chromenopyrimidobenzimidazolones chromenopyrazolopyrimidinones hemostasis 

Notes

Acknowledgments

The work was sponsored by RFBR Grant No. 16-03-00730.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • D. N. Ibragimova
    • 1
  • O. V. Fedotova
    • 1
  • A. G. Ozerova
    • 1
  • O. V. Koftin
    • 2
  • V. B. Borodulin
    • 2
  • V. A. Samokhvalov
    • 3
  1. 1.N. G. Chernyshevsky Saratov National Research State University (Saratov State University)SaratovRussia
  2. 2.V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian FederationSaratovRussia
  3. 3.University of AlbertaEdmontonCanada

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