3-Methyl-7-(1,1-dioxothietan-3-yl)-8-cyclohexylamino-1-ethyl-1H-purine-2,6(3H,7H)-dione was synthesized via the reaction of 8-bromo-3-methyl-7-(1,1-dioxothietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione and cyclohexylamine and exhibited antidepressant activity that was most pronounced at a dose of 1.6 mg/kg.
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References
M. D. Mashkovskii, Drugs [in Russian], Novaya Volna, Umerenkov (2014).
O. A. Ivanova, I. L. Nikitina, et al., RU Pat. 2,424,799, Jul. 27, 2011; Byull. Izobret., No. 21 (2011); http: //www1.fips.ru/Archive/PAT/2011FULL/2011.07.27/DOC/RUNWC1/000/000/002/424/799/document.pdf
T. Katsushima, L. Nieves, and J. Wells, J. Med. Chem., 33(7), 1906 – 1910 (1990).
F. A. Khaliullin, V. A. Kataev, and Yu. V. Strokin, Khim. Geterotsikl. Soedin., 4, 516 – 518 (1991).
F. A. Khaliullin, Yu. V. Shabalina, and R. M. Sharafutdinov, Zh. Org. Khim., 46(5), 698 – 701 (2010).
C. C. J. Culvenor, W. Davies, and K. H. Pausacker, J. Chem. Soc., 1050 – 1052 (1946).
M. A. Belen’kii, Elements of Quantitative Assessment of Pharmacological Effects [in Russian], Medgiz, Leningrad (1963).
V. V. Bagmetova, I. N. Tyurenkov, Yu. V. Chernysheva, and D. D. Borodin, Neuroscience for Medicine and Psychology. Collection of Scientific Articles of the IXth International Interdisciplinary Congress [in Russian], Moscow (2013), pp. 70 – 71.
E. V. Shchetinin, V. A. Baturin, E. B. Arushanyan, et al., Zh. Vyssh. Nervn. Deyat. im. I. P. Pavlova, 5, 958 – 964 (1989).
L. Steru, R. Chermat, B. Thierry, et al., Psychopharmacology, Berlin (1985).
L. A. Valeeva, G. G. Davlyatova, Yu. V. Shabalina, et al., Khim.-farm. Zh., 50(6), 8 – 11 (2016); Pharm. Chem. J., 50(6), 358 – 361 (2016).
R. A. Gabidullin, I. L. Nikitina, O. A. Ivanova, and E. K. Alekhin, RU Pat. Appl. No. 2008610170 (2009).
R. U. Khabriev, Handbook for Experimental (Preclinical) Trials of New Drugs [in Russian], Meditsina, Moscow (2005).
L. A. Valeeva and O. Yu. Godorazhi, Med. Vestn. Bashkortostana, 4(2), 186 – 188 (2009).
S. Glantz, Primer of Biostatistics, McGraw-Hill, New York (1997) [Russian translation, Praktika, Moscow (1998)].
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 12, pp. 3 – 6, December, 2017.
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Khaliullin, F.A., Shabalina, Y.V., Davlyatova, G.G. et al. Synthesis and Antidepressant Properties of 3-Methyl-7-(1,1-Dioxothietan-3-YL)-8-Cyclohexylamino-1-Ethyl-1H-Purine-2,6(3H,7H)-Dione. Pharm Chem J 51, 1049–1052 (2018). https://doi.org/10.1007/s11094-018-1738-0
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DOI: https://doi.org/10.1007/s11094-018-1738-0