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Experimental Antioxidant Activity of a β-Cyclodextrin – Histochrome Complex

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A2:1 β-cyclodextrin – histochrome complex was synthesized based on a comparison with experimental studies of histochrome and showed antioxidant activity prolonged to 16 d as compared with 6 d for histochrome in tests of the duration of the in vitro antioxidant effect. PMR measurements proved that a β-cyclodextrin – histochrome complex formed. Computer modeling of the β-cyclodextrin–histochrome complex showed that the head-to-tail complex corresponded to the energy minimum.

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Authors and Affiliations

  1. Ufa Eye Research Institute, Academy of Sciences of the Republic of Bashkortostan, Ufa, Bashkortostan, 450008, Russia

    M. M. Bikbov, N. A. Nikitin, V. K. Surkova & A. F. Nikitina

  2. Bashkir State Medical University, MH RF, Ufa, Bashkortostan, 450008, Russia

    R. R. Farkhutdinov

  3. Institute of Petrochemistry and Catalysis, Ufa Scientific Center, Russian Academy of Sciences, Ufa, Bashkortostan, 450054, Russia

    L. M. Khalilov & A. R. Tulyabaev

  4. G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch, Russian Academy of Sciences, Vladivostok, 690922, Russia

    S. A. Fedoreev & N. P. Mishchenko

Authors
  1. M. M. Bikbov
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  2. N. A. Nikitin
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  3. V. K. Surkova
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  4. R. R. Farkhutdinov
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  5. L. M. Khalilov
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  6. A. R. Tulyabaev
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  7. A. F. Nikitina
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  8. S. A. Fedoreev
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  9. N. P. Mishchenko
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 11, pp. 24 – 28, November, 2017.

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Bikbov, M.M., Nikitin, N.A., Surkova, V.K. et al. Experimental Antioxidant Activity of a β-Cyclodextrin – Histochrome Complex. Pharm Chem J 51, 980–984 (2018). https://doi.org/10.1007/s11094-018-1727-3

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  • DOI: https://doi.org/10.1007/s11094-018-1727-3

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