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L-Arginine – Cellulose-Acetate-Sulfate Complex and its Influence on Endothelial Dysfunction in Rats

The composition of a complex of L-arginine with cellulose acetate sulfate as the sodium salt was established. Its structure was characterized using computer simulation and spectroscopic methods. The Langmuir equation was shown to be applicable for describing adsorption isotherms of the complex on activated carbons of various origins. Amino acids were released from the immobilized complex predominantly in alkaline solution. The complex with 70-200 mg/kg of L-arginine exhibited pronounced cardioprotective activity and possessed antihypertensive and endothelioprotective action.

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Correspondence to T. A. Savitskaya.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 11, pp. 14 – 18, November, 2017.

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Shakhno, E.A., Savitskaya, T.A., Grinshpan, D.D. et al. L-Arginine – Cellulose-Acetate-Sulfate Complex and its Influence on Endothelial Dysfunction in Rats. Pharm Chem J 51, 970–974 (2018). https://doi.org/10.1007/s11094-018-1725-5

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  • DOI: https://doi.org/10.1007/s11094-018-1725-5

Keywords

  • L-arginine
  • cellulose acetate sulfate
  • activated carbon
  • immobilized complex
  • L-NAME
  • endothelial dysfunction