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L-Arginine – Cellulose-Acetate-Sulfate Complex and its Influence on Endothelial Dysfunction in Rats

The composition of a complex of L-arginine with cellulose acetate sulfate as the sodium salt was established. Its structure was characterized using computer simulation and spectroscopic methods. The Langmuir equation was shown to be applicable for describing adsorption isotherms of the complex on activated carbons of various origins. Amino acids were released from the immobilized complex predominantly in alkaline solution. The complex with 70-200 mg/kg of L-arginine exhibited pronounced cardioprotective activity and possessed antihypertensive and endothelioprotective action.

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  1. F. K. Johnson, R. A. Johnson, K. J. Peyton, and W. Durante, Am. J. Physiol.: Regul., Integr. Comp. Physiology, 288(4), 1057 – 1062 (2005).

    Google Scholar 

  2. D. S. Bredt and S. H. Snyder, Annu. Rev. Biochem., 63, 175 – 195 (1994).

    CAS  Article  PubMed  Google Scholar 

  3. T. Bagnost, A. Berthelot, M. Bouhaddi, et al., J. Hypertens., 26(6), 1110 – 1118 (2008).

    CAS  Article  PubMed  Google Scholar 

  4. E. A. Shakhno, T. A. Savitskaya, T. G. Pokrovskaya, et al., Res. Result: Pharmacol. Clin. Pharmacol., 2(1), 30 – 35 (2016).

    Google Scholar 

  5. N. P. Dmitrenko, T. O. Kishko, and S. G. Shandrenko, Ukr. Khim.-Ter. Zh., 2(22), 137 – 140 (2008).

    Google Scholar 

  6. Z. A. Rogovin, Cellulose Chemistry [in Russian], Khimiya, Moscow, 1972, pp. 11 – 14.

    Google Scholar 

  7. V. A. Simonyan, A. A. Salamotov, Yu. S. Pokrovskaya, et al., Use of Ninhydrin Reaction for Quantitative Determination of -Amino Acids in Various Objects. Methodical Recommendations [in Russian], Volgograd (2007), pp. 63 – 68.

  8. S. S. Voyutskii, Course in Colloid Chemistry [in Russian], Khimiya, Moscow (1975), pp. 88 – 99.

    Google Scholar 

  9. M. V. Pokrovskii, V. I. Kochkarov, T. G. Pokrovskaya, et al., Kuban. Nauch. Med. Vestn., 10(91), 72 – 77 (2006).

    Google Scholar 

  10. M. E. Galagan, A. V. Shirokolova, and A. F. Vanin, Vopr. Med. Khim., 37(1), 67 – 70 (1991).

    CAS  PubMed  Google Scholar 

  11. M. S. M. Eldin, E. A. Kamon, M. A. Sofan, et al., Arabian J. Chem., 8(3), 355 – 365 (2015).

    Article  Google Scholar 

  12. E. F. Strittmatter and E. R. Williams, J. Phys. Chem. A, 104(25), 6069 – 6076 (2000).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  13. T. G. Pokrovskaya, M. V. Pokrovskii, V. I. Kochkarov, et al., Ross. Med.-Biol. Vestn. im. I. P. Pavlova, 2, 126 – 131 (2008).

    Google Scholar 

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Correspondence to T. A. Savitskaya.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 11, pp. 14 – 18, November, 2017.

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Shakhno, E.A., Savitskaya, T.A., Grinshpan, D.D. et al. L-Arginine – Cellulose-Acetate-Sulfate Complex and its Influence on Endothelial Dysfunction in Rats. Pharm Chem J 51, 970–974 (2018).

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  • L-arginine
  • cellulose acetate sulfate
  • activated carbon
  • immobilized complex
  • L-NAME
  • endothelial dysfunction