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Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

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Pharmaceutical Chemistry Journal Aims and scope

Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.

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Acknowledgements

The authors are grateful to the Indian Council of Medical Research (New Delhi) for funding the project (58/15/2006-BMS). They are also thankful to the Manipal University for providing facilities during the project work.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, 576104, India

    T. N. V. Ganesh Kumar, G. Gautham Shenoy & Sidhartha Sankar Kar

  2. Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, 576104, India

    Vishnu Shenoy

  3. Department of Microbiology, Melaka-Manipal Medical College, Manipal University, Manipal, 576104, India

    Indira Bairy

Authors
  1. T. N. V. Ganesh Kumar
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  2. G. Gautham Shenoy
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  3. Sidhartha Sankar Kar
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  4. Vishnu Shenoy
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  5. Indira Bairy
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Correspondence to T. N. V. Ganesh Kumar.

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Ganesh Kumar, T.N.V., Gautham Shenoy, G., Kar, S.S. et al. Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis. Pharm Chem J 51, 907–917 (2018). https://doi.org/10.1007/s11094-018-1714-8

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  • DOI: https://doi.org/10.1007/s11094-018-1714-8

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