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Evaluation of Anti-Hyperglycemic Effect of Synthetic Schiff Base Vanadium(IV) Complexes

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Pharmaceutical Chemistry Journal Aims and scope

A chain of new vanadium(IV) complexes of Schiff bases, derived from acetohydrazide (HL1-3) or 4-aminoantipyrine (HL4-7) have been prepared and physicochemically distinguished using different tools including analytical, spectral, and magnetic techniques. The spectral and analytical data showed that ligands HL1-3 acted as neutral bidentate ligands, chelated through hydrazono carbonyl and azomethine groups, whereas HL4 acted as neutral tetradentate ligand coordinated via pyrazolone carbonyl, NH group, hydrazono carbonyl, and azo (N=N) groups forming binuclear complexes. The HL5 and HL6 behave as neutral bidentate ligands coordinating through pyrazolone carbonyl and NH groups; in case of ligand HL6, in addition to the mentioned mode, C=N and CN groups participated to bind a second VO(II) ion form binuclear complexes. HL7 behaves as a monobasic bidentate ligand bonded via deprotonated OH and azomethine groups. All complexes adopt square pyramidal geometry around vanadium ion. Results revealed that the oral management of vanadium complexes significantly reduced the blood glucose level in rats suffered from diabetes. The correction of altered biochemical parameters via treatment with vanadium complexes points the improved glucose balance.

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Acknowledgments

The authors are thankful to the Scientific Research Deanship, Qassim University, KSA, for financially supporting research project number 1201 (2012).

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Authors and Affiliations

  1. Department of Chemistry, College of Science, Qassim University, KSA, Buraydah, Saudi Arabia

    F. A. El-Saied

  2. Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt

    F. A. El-Saied

  3. Department of Biochemistry, College of Medicine, Qassim University, KSA, Buraydah, Saudi Arabia

    T. A. Salem

  4. Genetic Engineering and Biotechnology Research Institute, El Menoufia University, Sadat City, Egypt

    S. A. Aly

  5. Department of Chemistry, Faculty of Sciences and Arts, Khulais, University of Jeddah, Jeddah, Saudi Arabia

    M. M. E. Shakdofa

  6. Inorganic Chemistry Department, National Research Centre, Cairo, P. O. 12622 Dokki, Egypt

    M. M. E. Shakdofa

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  1. F. A. El-Saied
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  2. T. A. Salem
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  3. S. A. Aly
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  4. M. M. E. Shakdofa
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Correspondence to M. M. E. Shakdofa.

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El-Saied, F.A., Salem, T.A., Aly, S.A. et al. Evaluation of Anti-Hyperglycemic Effect of Synthetic Schiff Base Vanadium(IV) Complexes. Pharm Chem J 51, 833–842 (2017). https://doi.org/10.1007/s11094-017-1702-4

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  • DOI: https://doi.org/10.1007/s11094-017-1702-4

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