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Comparison of the Antitumor Efficacy of Bismuth and Gadolinium as Dose-Enhancing Agents in Formulations for Photon Capture Therapy

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The efficacy of photon capture therapy (PCT) is to a significant extent determined by the properties of the formulation containing the element efficiently absorbing external X-irradiation and operating as a dose-enhancing agent (DEA). We report here a comparison of the efficacies of bismuth and gadolinium as DEA in PCT technologies with X-irradiation at 110 kV for the treatment of superficial tumors. Bismuth and gadolinium are comparable in that they are available as the same chemical form – a complex with diethylenetriaminepentaacetic acid, for which the physicochemical properties are similar for both elements. Studies were performed on mice with transplanted B16F10 melanoma as a tumor model. Both DEAwere given by the intratumor route at the same dose of 5 mg of DEAper animal. Irradiation was with an x-ray apparatus with a tension of 110 kV using a dose of 20 Gy. The results showed significantly greater antitumor efficacy for PCT with both gadolinium and bismuth than with short-focus radiotherapy. In terms of the log dead cells (lgN), there was an increase in lgN from 0.78 for short-focus irradiation to 2.5 for PCT using gadolinium or bismuth, with identical dose exposure. There were no significant differences in the antitumor efficacies of PCT with bismuth and gadolinium for x-ray irradiation at 110 kV.

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Authors and Affiliations

  1. N. N. Blokhin Russian Oncological Scientific Center, 24 Kashirskoe Chaussee, Moscow, Russia

    A. A. Lipengol’ts, A. A. Cherepanov, E. Yu. Grigor’eva & I. B. Merkulova

  2. A. I. Burnazyan Federal Medical Biophysics Center, 46 Zhivopisnaya Street, Moscow, Russia

    A. A. Lipengol’ts, V. N. Kulakov & I. N. Sheino

  3. National Nuclear Research University MIFI, 31 Kashirskoe Chausee, Moscow, Russia

    A. A. Lipengol’ts

Authors
  1. A. A. Lipengol’ts
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  2. A. A. Cherepanov
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  3. V. N. Kulakov
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  4. E. Yu. Grigor’eva
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  5. I. B. Merkulova
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  6. I. N. Sheino
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 9, pp. 34 – 37, September, 2017.

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Lipengol’ts, A.A., Cherepanov, A.A., Kulakov, V.N. et al. Comparison of the Antitumor Efficacy of Bismuth and Gadolinium as Dose-Enhancing Agents in Formulations for Photon Capture Therapy. Pharm Chem J 51, 783–786 (2017). https://doi.org/10.1007/s11094-017-1693-1

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  • DOI: https://doi.org/10.1007/s11094-017-1693-1

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