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Seasonal Oscillations in Statistical Mean Measures of Blood Composition and Blood Cell Morphology in Healthy White Rats

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Pharmaceutical Chemistry Journal Aims and scope

The aim of the present work was to identify seasonal oscillations in the composition and morphology of the blood in intact rats. Morphometric measures of blood were determined in 36 clinically healthy adult male rats in different seasons (spring, summer, and autumn) using the Mekos programmable system. Seasonal oscillations within established reference ranges were found and these need to be considered when performing preclinical studies of medicines in relation to their efficacy and safety.

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Authors and Affiliations

  1. State Science Research Institute of Organic Chemistry and Technology, Moscow, Russia

    A. S. Pushkin, E. D. Drugova, S. A. Kamshilin, N. V. Obraztsov, O. V. Polekhina, S. I. Dvoretskaya & A. I. Churyumova

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  1. A. S. Pushkin
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  2. E. D. Drugova
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  3. S. A. Kamshilin
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  4. N. V. Obraztsov
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  5. O. V. Polekhina
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  6. S. I. Dvoretskaya
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  7. A. I. Churyumova
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Corresponding author

Correspondence to A. S. Pushkin.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 9, pp. 28 – 33, September, 2017.

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Pushkin, A.S., Drugova, E.D., Kamshilin, S.A. et al. Seasonal Oscillations in Statistical Mean Measures of Blood Composition and Blood Cell Morphology in Healthy White Rats. Pharm Chem J 51, 777–782 (2017). https://doi.org/10.1007/s11094-017-1692-2

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  • DOI: https://doi.org/10.1007/s11094-017-1692-2

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