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Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group

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Pharmaceutical Chemistry Journal Aims and scope

Interaction of 1-dimethylamino-4-diethylaminobutyn-2, 1-dimethylamino-4-piperidinobutyn-2, and 1-dimethylamino-4-morpholinobutyn-2 with the corresponding alkyl esters of monobromo(chloro)acetic acid was used to synthesize novel monoammonium salts. Studies of the antimicrobial activity of the resulting compounds showed that salts containing hydrophobic alkoxycarbonylmethyl radicals had marked antibacterial activity against Gram-positive and Gram-negative microorganisms.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Prospekt, 0014, Erevan, Armenia

    M. O. Manukyan, K. S. Barsegyan & A. Kh. Gyulnazaryan

  2. A. L. Mndzhoyan Institute of Fine Organic Chemistry, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Prospekt, 0014, Erevan, Armenia

    R. V. Paronikyan & G. M. Stepanyan

  3. Center for Molecular Structure Studies, Scientific-Technical Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Prospekt, 0014, Erevan, Armenia

    N. S. Minasyan

  4. Kh. Abovyan Armenian State Pedagogical University, 17 Tigran Metsi Prospekt, 0010, Erevan, Armenia

    M. O. Manukyan & A. V. Babakhanyan

Authors
  1. M. O. Manukyan
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  2. K. S. Barsegyan
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  3. A. Kh. Gyulnazaryan
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  4. R. V. Paronikyan
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  5. G. M. Stepanyan
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  6. N. S. Minasyan
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  7. A. V. Babakhanyan
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Corresponding author

Correspondence to M. O. Manukyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 9, pp. 15 – 19, September, 2017.

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Manukyan, M.O., Barsegyan, K.S., Gyulnazaryan, A.K. et al. Synthesis and Antimicrobial Properties of Ammonium Salts Containing a Substituted Butyn-2-yl Group. Pharm Chem J 51, 764–768 (2017). https://doi.org/10.1007/s11094-017-1689-x

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  • DOI: https://doi.org/10.1007/s11094-017-1689-x

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