A series of arylsubstituted tetrazolocyclanodihydropyrimidines was prepared and their cytotoxic actions on SPEV-2 cells were studied. The activity of these substances was found to depend on the nature and position of the substitution groups in the benzene ring and the size of the alicycle. The most active compounds were o-chloro(methyl)phenyltetrazolohexahydroquinazolines.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 9, pp. 8 – 11, September, 2017.
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Vasil’kova, N.O., Ivonin, M.A., Burygin, G.L. et al. Synthesis and Cytotoxic Activity of Arylsubstituted Tetrazolocyclanopyrimidines. Pharm Chem J 51, 756–759 (2017). https://doi.org/10.1007/s11094-017-1687-z
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DOI: https://doi.org/10.1007/s11094-017-1687-z