Pharmaceutical Chemistry Journal

, Volume 51, Issue 7, pp 627–633 | Cite as

Ce3+ Doped Clindamycin Nanoparticles Loaded in Gelatin Media: Study of Photoluminescence Properties and Antibacterial Effect

  • Sanaz Kazemzade Anari
  • Shahriar Ghammamy
  • Hossein Ghasemzadeh
  • Mohammad Reza Khanlary
DISCUSSIONS
  • 24 Downloads

In this work, Ce3+doped clindamycin nanoparticles (Ce3+/CLA-NP) loaded in gelatin media were prepared by sol-gel technique and characterized by x-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and photoluminescence (PL) spectra. The PL spectra of Ce3+/CLA-NP show two UV bands, at 325 and 355 nm, which are not detected from undoped CLA-NP. The morphology of the nanocomposite and the size of nanoparticles were estimated by scanning electron microscopy (SEM). The average particle size in Ce3+/CLA-NP was about 50 – 120 nm. The drug release profile was determined by UV–Vis spectroscopy. Finally, in vitro antibacterial properties of Ce3+/CLA-NP were evaluated against Staphylococcus aureus.

Keywords

doped nanoparticles Ce3+ drug delivery gelatin clindamycin antibacterial effect photoluminescence 

Notes

Acknowledgments

The authors are grateful to Dr. Mohsen Saneii and to the Imam Khomeini International University, Qazvin, for financing this research.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Sanaz Kazemzade Anari
    • 1
  • Shahriar Ghammamy
    • 1
  • Hossein Ghasemzadeh
    • 1
  • Mohammad Reza Khanlary
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceImam Khomeini International UniversityQazvinIran
  2. 2.Department of PhysicsImam Khomeini International UniversityQazvinIran

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