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Dehydration of 9a-Hydroxyandrost-4-ene-3,17-Dione in Organic Solvents

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

An effective method of dehydrating 9_-hydroxyandrost-4-ene-3,17-dione by mineral acids in organic solvents, producing essentially quantitative formation of androsta-4,9(11)-diene-3,17-dione is proposed. Quantitative isomerization of the side product androsta-4,8(9)-diene-3,17-dione to target product was shown to be pssible.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, Faculty of Chemistry, Building 3, 1 Lenin Heights, 119991, Moscow, Russia

    T. S. Savinova & N. V. Lukashev

  2. VietNam Academy of Science and Technology, Institute of Chemistry, 18 Hoàng Quoc Viet, Nghia Ðô, Cau Giay, Vietnam

    A. V. Kazantsev & Luu D. Huy

Authors
  1. T. S. Savinova
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  2. A. V. Kazantsev
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  3. Luu D. Huy
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  4. N. V. Lukashev
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Corresponding author

Correspondence to T. S. Savinova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 7, pp. 50 – 53, July, 2017.

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Savinova, T.S., Kazantsev, A.V., Huy, L.D. et al. Dehydration of 9a-Hydroxyandrost-4-ene-3,17-Dione in Organic Solvents. Pharm Chem J 51, 612–615 (2017). https://doi.org/10.1007/s11094-017-1662-8

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  • DOI: https://doi.org/10.1007/s11094-017-1662-8

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