Pharmaceutical Chemistry Journal

, Volume 51, Issue 7, pp 602–605 | Cite as

Biologically Active Substances From Dropwort (Filipendula vulgaris) and Assessment of Their Antioxidant Properties

  • I. V. ShilovaEmail author
  • E. I. Korotkova

This study demonstrated the antioxidant activity of aqueous and aqueous-ethanolic (40%, 70%, 95%) extracts of the above-ground parts of the dropwort (Filipendula vulgaris Moench) in relation to the process of electroreduction of oxygen. Antioxidant properties were more marked in the more lipophilic dropwort extract. The lipophilic fraction of the aqueous extract (extracted with ethyl acetate) had marked antioxidant activity, and its efficacy was greater than those of dihydroquercetin and ascorbic acid, and this resulted from the more complete extraction of total biologically active compounds of phenolic (simple phenols, flavonoids, hydroxycoumarins, phenolcarboxylic acids) and triterpene (acids, saponins) nature, as well as amino acids.


Filipendula vulgaris Moench phenolic and triterpene compounds cathodic voltammetry 


  1. 1.
    Yu. A. Sukhomlinov, M. V. Pokrovskii, A. I. Konoplya, et al., Vestn. Voronezhskogo Gos. Un-ta, Khim. Biol. Farm., 2, 209 – 213 (2005).Google Scholar
  2. 2.
    M.-L. Popescu, V. Istudor, C. Parvu, et al., Farmacia (Romania), 50(2), 34 – 38 (2002).Google Scholar
  3. 3.
    Russian Federation Patent RF 2394588; Byul. Izobret., No. 20 (2010).Google Scholar
  4. 4.
    I. V. Shilova and N. I. Suslov, Vestnik Farmatsii, 64(2), 84 – 89 (2014).Google Scholar
  5. 5.
    I. V. Shilova and N. I. Suslov, Byul. Éksper. Biol. Med., 158(11), 609 – 613 (2014).Google Scholar
  6. 6.
    H. D. Smolarz and A. Sokolowska-Wozniak, Chem. Environment. Res., 12(1), 77 – 82 (2003).Google Scholar
  7. 7.
    N. I. Grinkevich and L. N. Safronich (eds.), Chemical Analysis of Medicinal Herbs [in Russian], Vysshaya Shkola, Moscow (1983).Google Scholar
  8. 8.
    N. P. Maksyutina (ed.), Medicinal Herbs [in Russian], Zdorov’ya, Kiev (1985).Google Scholar
  9. 9.
    V. L. Bagirova and V. A. Severtsev (ed.), Infusions, Extracts, Elixirs, and their Standardization [in Russian], SpetsLit, St. Petersburg (2001).Google Scholar
  10. 10.
    I. Schepetkin, A. Potapov, A. Khlebnikov, et al., J. Biol. Inorg. Chem., 11, 499 – 513 (2006).CrossRefPubMedGoogle Scholar
  11. 11.
    I. V. Shilova, A. A. Semenov, N. I. Suslov, et al., Khim.-Farm. Zh., 43(4), 7 – 11 (2009); Pharm. Chem. J., 43(4), 185 – 190 (2009).Google Scholar
  12. 12.
    T. A. Voronina and S. B. Seredenin, Éksper. Klin. Farmakol., 70(4), 44 – 58 (2007).Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.E. D. Goldberg Science Research Institute of Pharmacology and Regenerative MedicineTomskRussia
  2. 2.Tomsk State National Research UniversityTomskRussia
  3. 3.Tomsk National Research Polytechnic UniversityTomskRussia

Personalised recommendations