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Pharmaceutical Chemistry Journal

, Volume 51, Issue 7, pp 576–581 | Cite as

Synthesis and Antinociception Activities of New Substituted Aminobenzothiazole Analogs of Lidocaine

  • Abbas Ahmadi
  • Mohsen Khalili
  • Javad Hasanabadi
  • Mahnaz Rezavil
  • Babak Nahri-Niknafs
Article
  • 175 Downloads

Local anesthetics are the most widely used drugs in practical medicine which provide the loss of sensation in a specific body part without loss of consciousness or impairment of central control of vital functions. Lidocaine (I) is the most common local anesthetic drug which has been widely used in all cases because of its excellent diffusing and penetrating properties as well as rapid onset of surgical analgesia. In this study, new aminobenzothiazole analogs (with many useful biological and pharmacological properties) were synthesized by changing the amine moiety of I. The acute and chronic pain properties of new compounds (II – VI) were studied using the tail immersion and formalin tests on mice and the results were compared to control and lidocaine groups. According to the obtained results, aminobenzothiazole derivatives are better candidates than diethylamine group for replacement in the amine moiety of I. In addition, derivatives with electron-withdrawing groups on this amine (V and VI) could decrease pain better than compounds (II and III) with electron-donating groups (especially in position 6 of this amine, II and V) which may be concern to more blockades of specific sodium channels by these compounds.

Keywords

lidocaine local anesthetics aminobenzothiazole acute pain chronic pain tail immersion test formalin test 

Notes

Acknowledgements

This work was a research project at Islamic Azad University and the authors would like to express their gratitude to it. They thank Fariba Ansari for her assistance in pharmacological tests. They also appreciate Mojtaba Chaichi, EFL/ESL educator at Safir Plus English Language Academy, for proofreading the initial draft of this article.

Conflict of Interest

Authors declare no conflict of interests.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Abbas Ahmadi
    • 1
  • Mohsen Khalili
    • 2
  • Javad Hasanabadi
    • 1
  • Mahnaz Rezavil
    • 1
  • Babak Nahri-Niknafs
    • 1
  1. 1.Department of Chemistry, Faculty of Science, Karaj BranchIslamic Azad UniversityKarajIran
  2. 2.Neurophysiology Research CenterShahed UniversityTehranIran

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