Pharmaceutical Chemistry Journal

, Volume 51, Issue 7, pp 553–557 | Cite as

Synthesis and Biological Properties of {[(4-Hydroxy-1-Methyl-2,2-Dioxido-1H-2,1-Benzothiazin-3-YL)Carbonyl]Amino}-Benzoic Acids and Their Derivatives

  • I. V. Ukrainets
  • L. A. Petrushova
  • S. P. Dzyubenko
  • L. A. Grinevich
  • G. Sim
Article
  • 33 Downloads

Continuing the search for novel biologically active substances among the 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides series, we report here the synthesis of a series of {[(4-hydroxy-1-methyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)carbonyl]amino} benzoic acids asd their derivatives at the carboxyl group. Pharmacological testing showed that compounds with a free carboxyl group are of interest as potential diuretics, while carbamide derivatives have potential as analgesics. Esterification of the carboxyl group with lower alkyl alcohols was less effective.

Keywords

aminobenzoic acids anilides 4-hydroxy-2,1-benzothiazines synthesis analgesic acid diuretic actions 

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • L. A. Petrushova
    • 2
  • S. P. Dzyubenko
    • 3
  • L. A. Grinevich
    • 1
  • G. Sim
    • 3
  1. 1.National Pharmaceutical UniversityKharkovUkraine
  2. 2.Vinnitsa N. I. Pirogov National Medical UniversityVinnitsaUkraine
  3. 3.Far East State Medical UniversityKhabarovskRussia

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