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Pharmaceutical Chemistry Journal

, Volume 51, Issue 7, pp 546–549 | Cite as

Synthesis and Antiarrhythmic Activity of 1-Benzyl-3,3-Dialkyl-3,4-Dihydroisoquinoline Chlorides

  • A. G. Mikhailovskii
  • O. V. Gashkova
  • I. P. Rudakova
  • D. A. Peretyagin
Article
  • 46 Downloads

Cyclocondensation of dialkylbenzylcarbinols with benzylcyanides was used to synthesize 1-benzyl-3,3-dialkyl-3,4-dihydroisoquinolines. The hydrochlorides of the compounds synthesized here were tested for antiarrhythmic activity in a calcium chloride model. The maximum antiarrhythmic index (AI) was found with isoquinolines with cycloalkanone fragments such as cyclopentanone and cyclohexanone in position 3, which had AI values of 15.5 and 16.3, three times the corresponding value for lidocaine.

Keywords

cyclocondensation dialkylbenzylcarbinones benzylcyanides 1-benzyl-3,3-dialkyl-3,4-dihydroisoquinoline chlorides antiarrhythmic actions calcium chloride model lidocaine 

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • A. G. Mikhailovskii
    • 1
  • O. V. Gashkova
    • 1
  • I. P. Rudakova
    • 1
  • D. A. Peretyagin
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia

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