Pharmaceutical Chemistry Journal

, Volume 51, Issue 7, pp 533–539 | Cite as

Synthesis and Antidiabetic Activity of Thiazolo[2,3-f]Purine Derivatives and Their Analogs

  • A. A. Spasov
  • F. A. Khaliullin
  • D. A. Babkov
  • G. A. Timirkhanova
  • V. A. Kuznetsova
  • L. V. Naumenko
  • D. R. Muleeva
  • O. Yu. Maika
  • T. Yu. Prokhorova
  • E. A. Sturova
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Thiazolo[2, 3-f]purine derivatives and their analogs – dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine, and 8-(2-hydroxypropylthio)purine derivatives – were synthesized. The compounds synthesized here had no effects on protein glycation reactions using glucose; they gave weak inhibition of glycogen phosphorylase; they had no hemorheological activity. Substances with hypotensive activity greater than that of Dibazol were found. A number of substances had hypoglycemic effects greater than those of chlorpropamide and Adebit. Two compounds inhibited dipeptidylpeptidase-4, but were less active than reference agent vildagliptin.

Keywords

thietanes purine antidiabetic activity 

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • A. A. Spasov
    • 1
  • F. A. Khaliullin
    • 2
  • D. A. Babkov
    • 1
  • G. A. Timirkhanova
    • 2
  • V. A. Kuznetsova
    • 1
  • L. V. Naumenko
    • 1
  • D. R. Muleeva
    • 1
  • O. Yu. Maika
    • 1
  • T. Yu. Prokhorova
    • 1
  • E. A. Sturova
    • 1
  1. 1.Volgograd State Medical University, Ministry of Health of the Russian FederationVolgogradRussia
  2. 2.Bashkir State Medical University, Ministry of Health of the Russian FederationUfaRussia

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