Pharmaceutical Chemistry Journal

, Volume 51, Issue 7, pp 523–527 | Cite as

Modification of the Antitumor Action of Cytostatic Drugs Using a Copolymer of N-Vinylpyrrolidone and 2-Methyl-5-Vinylpyridine

  • A. V. Panov
  • Yu. V. Kochkina
  • E. I. Yartsev
  • D. V. Eremin
  • T. A. Yakovleva
  • S. A. Kedik
MOLECULAR BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Simultaneous administration of a copolymer of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine and cytostatic agents to mice with a variety of implanted tumors was found to increase treatment efficacy, promoting increases in survival time. This effect is of interest for further studies of the possible use of copolymer as an immunomodulator in chemotherapy.

Keywords

N-vinylpyrrolidone 2-methyl-5-vinylpyridine copolymer cytostatic antitumor effect immunomodulator 

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • A. V. Panov
    • 1
    • 2
  • Yu. V. Kochkina
    • 1
    • 2
  • E. I. Yartsev
    • 2
  • D. V. Eremin
    • 1
    • 2
  • T. A. Yakovleva
    • 2
  • S. A. Kedik
    • 1
    • 2
  1. 1.Moscow Technology University (MITKhT)MoscowRussia
  2. 2.Institute of Pharmaceutical TechnologiesMoscowRussia

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