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Modification of the Antitumor Action of Cytostatic Drugs Using a Copolymer of N-Vinylpyrrolidone and 2-Methyl-5-Vinylpyridine

  • MOLECULAR BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

Simultaneous administration of a copolymer of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine and cytostatic agents to mice with a variety of implanted tumors was found to increase treatment efficacy, promoting increases in survival time. This effect is of interest for further studies of the possible use of copolymer as an immunomodulator in chemotherapy.

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References

  1. S. A. Kedik, S. V. Vorozhtsova, E. I. Yartsev, et al., Vopr. Biol. Med. Farm. Khimii, 8, 32 – 35 (2012).

  2. Russian Federation Patent RF No. 2471491 (2011).

  3. Russian Federation Patent RF No. 2430933 (2010).

  4. Russian Federation Patent RF No. 2430932 (2010)

  5. S. A. Kedik, A. V. Panov, I. V. Sakaeva, et al., Khim.-Farm. Zh., 46(8), 110 – 113 (2012); Pharm. Chem. J., 46(8), 478 – 481 (2012).

  6. S. A. Kedik, A. V. Panov, I. V. Sakaeva, et al., Khim.-Farm. Zh., 47(10), 54 – 56 (2013); Pharm. Chem. J., 47(10), 569 – 571 (2013).

  7. S. A. Kedik, E. A. Yartsev, O. A. Bocharova, I. V. Sakaeva, Vopr. Biol. Med. Farm. Khimii, 9, 30 – 32 (2010).

    Google Scholar 

  8. J. Kohlman and C.-G. Rem, Vivid Biochemistry]Russian translation], Mir, Moscow (1998).

  9. Clinical Pharmacology [in Russian], Yu. B. Belousov, V. G. Kukes, V. K. Lepakhin, and V. I. Petrov (eds.), GÉOTAR-Media, Moscow (2009).

  10. V. S. Kalistratova, A. A. Ivanov, and P. G. Nisimov, Radiats. Biol. Radioékol., 41(1), 104 – 112 (2001).

    CAS  Google Scholar 

  11. G. V. Kalistratov, S. A. Kedik, and V. I. Svergun, Med. Radiol., 38(10), 21 – 25 (1993).

    CAS  Google Scholar 

  12. Russian Federation Patent RF 2459838 (2012).

  13. Yu. V. Buklis, Morfologiya, 137, No. 4, 42 (2010).

  14. A. V. Panov, O. S. Izmest’eva, E. I. Selivanova, et al., Radiatsiya i Risk, 1, 65 – 75 (2016).

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Authors and Affiliations

  1. Moscow Technology University (MITKhT), 86 Vernadskii Prospekt, 119571, Moscow, Russia

    A. V. Panov, Yu. V. Kochkina, D. V. Eremin & S. A. Kedik

  2. Institute of Pharmaceutical Technologies, 21/32 Skolkovskoe Chaussee, 121353, Moscow, Russia

    A. V. Panov, Yu. V. Kochkina, E. I. Yartsev, D. V. Eremin, T. A. Yakovleva & S. A. Kedik

Authors
  1. A. V. Panov
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  2. Yu. V. Kochkina
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  3. E. I. Yartsev
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  4. D. V. Eremin
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  5. T. A. Yakovleva
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  6. S. A. Kedik
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Corresponding author

Correspondence to Yu. V. Kochkina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 7, pp. 3 – 7, July, 2017.

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Panov, A.V., Kochkina, Y.V., Yartsev, E.I. et al. Modification of the Antitumor Action of Cytostatic Drugs Using a Copolymer of N-Vinylpyrrolidone and 2-Methyl-5-Vinylpyridine. Pharm Chem J 51, 523–527 (2017). https://doi.org/10.1007/s11094-017-1647-7

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  • DOI: https://doi.org/10.1007/s11094-017-1647-7

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