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The Main Structural Types of Inhibitors of Matrix Metalloproteinases

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Pharmaceutical Chemistry Journal Aims and scope

This review addresses the main structural types of matrix metalloproteinase (MMP) inhibitors - hydroxamic acid derivatives, sulfonamides, bisphosphonates, compounds combining phosphoryl and hydroxamate groups, and functional derivatives of phosphonic and phosphinic acids. The selectivity of the inhibitory actions of these substances in relation to different types of MMP and the potential for the practical application of these substances in cancer treatment are discussed.

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Authors and Affiliations

  1. Samara State Technical University, 244 Molodogvardeiskaya Street, 443100, Samara, Russia

    L. E. Kapranov, A. N. Reznikov & Yu. N. Klimochkin

Authors
  1. L. E. Kapranov
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  2. A. N. Reznikov
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  3. Yu. N. Klimochkin
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Corresponding author

Correspondence to A. N. Reznikov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 3, pp. 13 – 19, March, 2017.

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Kapranov, L.E., Reznikov, A.N. & Klimochkin, Y.N. The Main Structural Types of Inhibitors of Matrix Metalloproteinases. Pharm Chem J 51, 175–181 (2017). https://doi.org/10.1007/s11094-017-1577-4

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  • DOI: https://doi.org/10.1007/s11094-017-1577-4

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