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Synthesis and Antiviral Properties of Ethyl(3-ethyladamant-1-yl)carbamate

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The new adamantine derivative ethyl(3-ethyladamant-1-yl)carbamate was found to have high antiviral activity against herpes simplex virus and vaccinia viruses, as well as adenovirus (EC50 = 0.62, 5.15, and 48.5 μg/ml respectively). Activity against the herpesvirus was demonstrated in experiments in various cell cultures using different virus strains, including a variant resistant to acycloguanosine (ACG). Simultaneous application of ethyl(3-ethyladamant-1-yl)carbamate and ACG increased the inhibition of herpesvirus reproduction in cell cultures and decreased the mortality of laboratory animals with experimental herpesvirus neuroinfection as compared with the use of each substance alone. 3-Ethyladamant-1-yl)carbamate was a low-toxicity compound, did not inhibit DNAsynthesis in uninfected cell cultures, and its acute intragastric LD50 for white mice was 1831.8 mg/kg.

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Authors and Affiliations

  1. Samara State Technical University, 244 Molodogvardeiskaya Street, 443100, Samara, Russia

    Yu. N. Klimochkin, I. K. Moiseev & M. V. Leonova

  2. Republican Scientific Applied Center for Epidemiology and Microbiology, Ministry of Health of the Republic of Belarus, 23 Filimonov Street, 220114, Minsk, Belarus

    S. N. Nikolaeva & E. I. Boreko

Authors
  1. Yu. N. Klimochkin
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  2. I. K. Moiseev
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  3. M. V. Leonova
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  4. S. N. Nikolaeva
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  5. E. I. Boreko
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Corresponding author

Correspondence to Yu. N. Klimochkin.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 1, pp. 15 – 19, January, 2017.

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Klimochkin, Y.N., Moiseev, I.K., Leonova, M.V. et al. Synthesis and Antiviral Properties of Ethyl(3-ethyladamant-1-yl)carbamate. Pharm Chem J 51, 13–17 (2017). https://doi.org/10.1007/s11094-017-1548-9

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  • DOI: https://doi.org/10.1007/s11094-017-1548-9

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