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Antitumor Activity of a Polymer Composite of Etoposide and Biodegradable Poly(Lactide-Co-Glycolide)

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Pharmaceutical Chemistry Journal Aims and scope

A method for preparing an antitumor polymer form of etoposide (PFE) as submicron particles based on poly(lactide-co-glycolide) with a 50:50 ratio of monomers (PLGA 50/50) was described. It was shown that the PFE possessed high cytotoxicity against various types of human tumor cells. The activity of the PFE against multiple drug resistant K562ADR cell line was greater than that of free etoposide. A grafted solid P388 murine lymphatic leukemia model showed that the PFE exhibited high in vivo antitumor activity that was prolonged compared with that of free etoposide.

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References

  1. J. A. Sinkule, Pharmacotherapy, 4(2), 61 – 73 (1984).

    Article  CAS  PubMed  Google Scholar 

  2. T. G. Gantchev and D. J. Hunting, Anti-cancer Drugs, 8(2), 164 – 173 (1997).

  3. http: // www.rlsnet.ru / mnn index id 277.htm#primenenie-veshhestva-ehtopozid

  4. O. Bruserud, H. Reikvam, A. O. Kittang, et al., Cancer Chemother. Pharmacol., 70(6), 765 – 782 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. S. N. Wolff, M. F. Fer, C. M. McKay, et al., J. Clin. Oncol., 1(11), 701 – 705 (1983).

    CAS  PubMed  Google Scholar 

  6. J. Ciccolini, S. Monjanel-Mouterde, S. S. Bun, et al., Ther. Drug Monit., 24(6), 709 – 714 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. W. Y. Qian, D. M. Sun, R. R. Zhu, et al., Int. J. Nanomed., 7, 5781 – 5792 (2012).

    CAS  Google Scholar 

  8. R. Saadati, S. Dadashzadeh, Z. Abbasian, and H. Soleimanjahi, Pharm. Res., 30(4), 985 – 995 (2013).

    Article  CAS  PubMed  Google Scholar 

  9. G. Yordanov, R. Skrobanska, and A. Evangelatov, Colloids Surf., B, 101, 215 – 222 (2013).

  10. K. S. Yadav, S. Jacob, G. Sachdeva, and K. K. Sawant, J. Nanosci. Nanotechnol., 11(8), 6657 – 6667 (2011).

  11. M. Snehalatha, K. Venugopal, R. N. Saha, et al., Drug Delivery, 15(5), 277 – 287 (2008).

    Article  CAS  PubMed  Google Scholar 

  12. J.-M. Lu, X. Wang, C. Marin-Muller, et al., Expert Rev. Mol. Diagn., 9(4), 325 – 341 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. T. J. Mossmann, Immunol. Methods, 65, 55 – 63 (1983).

    Article  Google Scholar 

  14. Handbook of Preclinical Drug Trials [in Russian], Part 1, Grif iK, Moscow (2012), pp. 640 – 654.

Download references

Acknowledgments

The work was supported financially by subsidy No. 14.604.21.0072 under the project “Technology development for producing polymer drug forms for treating oncological diseases” under the auspices of the FTP “Research and development in priority areas of the Russian science and technology complex for 2014 – 2020.” The unique identifier of the applied research (project) is RFMEFI60414X0072.

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Authors and Affiliations

  1. National Research Centre Kurchatov Institute, 1 Akad. Kurchatov Sq., Moscow, 123182, Russia

    G. A. Posypanova, L. B. Gorshkova, A. V. Rodina, Yu. P. Semochkina, V. G. Perevozchikova, E. Yu. Moskaleva, M. G. Ratushnyak, E. A. Vorontsov, S. L. Kuznetsov, I. A. Tubasheva, A. I. Murav’eva & S. E. Severin

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  1. G. A. Posypanova
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  2. L. B. Gorshkova
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  3. A. V. Rodina
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  4. Yu. P. Semochkina
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  5. V. G. Perevozchikova
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  6. E. Yu. Moskaleva
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  7. M. G. Ratushnyak
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  8. E. A. Vorontsov
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  9. S. L. Kuznetsov
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  10. I. A. Tubasheva
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  11. A. I. Murav’eva
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  12. S. E. Severin
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Corresponding author

Correspondence to E. Yu. Moskaleva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 8, pp. 45 – 49, August, 2016.

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Posypanova, G.A., Gorshkova, L.B., Rodina, A.V. et al. Antitumor Activity of a Polymer Composite of Etoposide and Biodegradable Poly(Lactide-Co-Glycolide). Pharm Chem J 50, 543–547 (2016). https://doi.org/10.1007/s11094-016-1486-y

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  • DOI: https://doi.org/10.1007/s11094-016-1486-y

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