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Synthesis and Antiproliferative Activity of New Acylcatechins

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Pharmaceutical Chemistry Journal Aims and scope

New peracyl derivatives of the natural flavonoid (±)-catechin were synthesized. It was shown that carboxylic-acid acyl residues enhanced to various degrees the cytotoxicity of peracyl catechins against HeLa cell line. The structures of the synthesized compounds were confirmed by PMR and 13C NMR spectroscopy and elemental analysis. The catechins were compared with previously studied analogous dihydroquercetin derivatives.

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References

  1. É. E. Nifant’ev, A. M. Koroteev, A. O. Pozdeev, et al., Khim.-farm. Zh., 49(2), 8 – 11 (2015); Pharm. Chem. J., 49(2), 78 – 81 (2015).

  2. M. P. Koroteev, A. O. Pozdeev, A. M. Koroteev, et al., Butler. Soobshch., 39(10), 94 – 120 (2014).

    Google Scholar 

  3. É. E. Nifant’ev, S. E. Mosyurov, T. S. Kukhareva, et al., Dokl. Akad. Nauk, 468(1), 44 – 47 (2016).

    Google Scholar 

  4. A. J. Gordon and R. A. Ford, The Chemist’s Companion, Wiley-Interscience, New York (1972) [Russian translation, Mir, Moscow (1976), pp. 437 – 444].

  5. A. N. Mironov (ed.), Handbook of Preclinical Drug Trials [in Russian], Grif i K, Moscow (2012).

    Google Scholar 

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Acknowledgments

The work was supported financially by the RF Ministry of Education and Science (State Task) and the RFBR (Grant 12-03-00362-a).

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Authors and Affiliations

  1. Institute of Biology and Chemistry, Department of Organic Chemistry, Moscow State Pedagogical University, 3 Nesvizhskii Per., Moscow, 119021, Russia

    A. O. Pozdeev, E. N. Rasadkina, A. A. Burym, M. P. Koroteev & A. M. Koroteev

  2. Medical-Biology Department, Pirogov Russian National Research Medical University, 9A/1 Bol’shaya Pirogovskaya St., Moscow, 119435, Russia

    V. V. Knyazev, A. I. Matyushin, A. V. Semeikin & N. L. Shimanovskii

Authors
  1. A. O. Pozdeev
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  2. E. N. Rasadkina
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  3. A. A. Burym
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  4. V. V. Knyazev
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  5. M. P. Koroteev
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  6. A. I. Matyushin
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  7. A. M. Koroteev
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  8. A. V. Semeikin
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  9. N. L. Shimanovskii
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Corresponding author

Correspondence to A. O. Pozdeev.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 8, pp. 26 – 28, August, 2016.

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Pozdeev, A.O., Rasadkina, E.N., Burym, A.A. et al. Synthesis and Antiproliferative Activity of New Acylcatechins. Pharm Chem J 50, 523–525 (2016). https://doi.org/10.1007/s11094-016-1481-3

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  • DOI: https://doi.org/10.1007/s11094-016-1481-3

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