A series of methyl 3-acyl-6-amino-4-aryl-5-cyano-4H-pyran-2-carboxylates were synthesized using the reaction of methyl 2,4-dioxobutanoates with arylidenemalononitriles in EtOAc in the presence of catalytic amounts of morpholine or piperidine. The structures of the compounds were elucidated using IR, PMR, 13C NMR, and mass spectral data. The antimicrobial, analgesic, and antipyretic activities of the synthesized compounds and their influence on antibody response were studied.
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The work was sponsored by RSF Grant No. 15-13-10029.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 8, pp. 22 – 25, August, 2016.
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Mar’yasov, M.A., Davydova, V.V., Sheverdov, V.P. et al. Synthesis and Antimicrobial, Analgesic, Antipyretic, and Immunotropic Activity of Methyl 3-Aryl-6-Amino-4-Aryl-5-Cyano-4H-Pyran-2-Carboxylates. Pharm Chem J 50, 519–522 (2016). https://doi.org/10.1007/s11094-016-1480-4
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DOI: https://doi.org/10.1007/s11094-016-1480-4