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Effects of Melaxen and Valdoxan on Free-Radical Oxidation in Rat Heart with Experimental Hyperthyroidism

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Pharmaceutical Chemistry Journal Aims and scope

The rate of free-radical oxidation in rat heart with experimental hyperthyroidism (EH) was estimated after Melaxen and Valdoxan administration. It was found that the content of protein carbonyl groups increased if the pathology developed in cardiomyocytes. This indicated that they were oxidized. Increased concentrations of primary lipid peroxidation products (diene conjugates), inhibition of aconitate hydratase activity, and accumulation of citrate were noted. Injection of Melaxen and Valdoxan to rats with EH normalized these parameters. The melatonin-correcting capability of the used drugs and the antioxidant activity of melatonin probably facilitated normalization of free-radical homeostasis in rat cardiomyocytes with the pathology.

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Acknowledgments

The work was sponsored by the Russian Ministry of Education and Science under a state task to higher educational institutions for scientific activity in 2014 – 2016, Project No. 1090.

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Authors and Affiliations

  1. Voronezh State University, Voronezh, 394006, Russia

    T. N. Popova, A. A. Agarkov, M. V. Gorbenko & K. K. Shul’gin

  2. N. N. Burdenko Voronezh State Medical University, Voronezh, Russia

    S. S. Popov

Authors
  1. T. N. Popova
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  2. A. A. Agarkov
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  3. M. V. Gorbenko
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  4. S. S. Popov
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  5. K. K. Shul’gin
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 8, pp. 7 – 11, August, 2016.

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Popova, T.N., Agarkov, A.A., Gorbenko, M.V. et al. Effects of Melaxen and Valdoxan on Free-Radical Oxidation in Rat Heart with Experimental Hyperthyroidism. Pharm Chem J 50, 505–508 (2016). https://doi.org/10.1007/s11094-016-1477-z

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  • DOI: https://doi.org/10.1007/s11094-016-1477-z

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