A four-step synthesis of abiraterone acetate in good yield was developed. The synthesis employed Suzuki cross-coupling in the key step and produced the target compound in 99.8% purity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 6, pp. 36 – 38, June, 2016.
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Balaev, A.N., Gromyko, A.V. & Fedorov, V.E. Four-Step Synthesis of Abiraterone Acetate from Dehydroepiandrosterone. Pharm Chem J 50, 404–406 (2016). https://doi.org/10.1007/s11094-016-1459-1
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DOI: https://doi.org/10.1007/s11094-016-1459-1