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Pharmaceutical Chemistry Journal

, Volume 50, Issue 6, pp 404–406 | Cite as

Four-Step Synthesis of Abiraterone Acetate from Dehydroepiandrosterone

  • A. N. Balaev
  • A. V. Gromyko
  • V. E. Fedorov
DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY

A four-step synthesis of abiraterone acetate in good yield was developed. The synthesis employed Suzuki cross-coupling in the key step and produced the target compound in 99.8% purity.

Keywords

abiraterone acetate manufacturing androgen biosynthesis inhibitor 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • A. N. Balaev
    • 1
  • A. V. Gromyko
    • 1
  • V. E. Fedorov
    • 1
  1. 1.Pharm-Sintez Co.MoscowRussia

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