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Synthesis and Immunotropic Activity of Quinazolin-4(3H)-One Carbonyl Derivatives

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Pharmaceutical Chemistry Journal Aims and scope

Novel benzannelated pyrimidines, i.e., quinazolin-4(3H)-one derivatives, were synthesized and studied experimentally for possible immunotropic properties. Immunocorrection properties were observed for some substances (VMA-13, Nos. 01-04) with respect to immunosuppression caused by cyclophosphamide.

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References

  1. V. M. Man’ko, R. V. Petrov, and R. M. Khaitov, Immunologiya, 23(3), 132 – 138 (2002).

    Google Scholar 

  2. R. M. Khaitov and B. V. Pinegin, Klin. Med., No. 8, 7 – 13 (1996).

  3. A. N. Mironov (ed.), Handbook for Preclinical Drug Trials [in Russian], Part 1, Grif i K, Moscow (2012), pp. 624 – 639.

  4. Yu. S. Maklyakov, E. V. Ivanova, S. A. Ovchar, et al., Biomeditsina, No. 2, 117 – 121 (2006).

  5. A. A. Ozerov, M. S. Novikov, Yu. A. Timofeeva, et al., Vestn. Volg. Gos. Med. Univ., No. 3, 10 – 17 (2012).

  6. A. O. Osipov, P. P. Purygin, A. V. Dubishchev, et al., Vestn. Samar. Gos. Univ., Estestvennonauchn. Ser., 89(8), 167 – 172 (2011).

  7. G. Andrei, R. Sienaert, C. McGuigan, et al., Antimicrob. Agents Chemother., 49(3), 1081 – 1086 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. E. D. Clercq, G. Ferir, S. Kaptein, et al., Viruses, 2(6), 1279 – 1305 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Ministry of the Russian Federation for Health and Social Development Order No. 708-n of Aug. 23, 2010, “On approval of Good Laboratory Practice” [in Russian], Moscow (2010).

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Authors and Affiliations

  1. Astrakhan State Medical Academy, RF Ministry of Health, 121 Bakinskaya St, Astrakhan, 414000, Russia

    M. A. Samotrueva & A. A. Tsibizova

  2. Leprosy Research Institute, RF Ministry of Health, 3 N. Ostrovskogo Pr, Astrakhan, 414057, Russia

    M. A. Samotrueva & S. A. Luzhnova

  3. Volgograd State Medical University, RF Ministry of Health, 1 Pavshikh Bortsov Sq, Volgograd, 400131, Russia

    A. A. Ozerov, E. G. Glukhova & I. N. Tyurenkov

Authors
  1. M. A. Samotrueva
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  2. A. A. Tsibizova
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  3. A. A. Ozerov
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  4. S. A. Luzhnova
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  5. E. G. Glukhova
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  6. I. N. Tyurenkov
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Corresponding author

Correspondence to M. A. Samotrueva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 6, pp. 12 – 14, June, 2016.

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Samotrueva, M.A., Tsibizova, A.A., Ozerov, A.A. et al. Synthesis and Immunotropic Activity of Quinazolin-4(3H)-One Carbonyl Derivatives. Pharm Chem J 50, 362–364 (2016). https://doi.org/10.1007/s11094-016-1452-8

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  • DOI: https://doi.org/10.1007/s11094-016-1452-8

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