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Synthesis, Structure, and Analgesic Properties of Phosphorylated Dihydro-1,4-Benzodiazepin-2-Ones*

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Pharmaceutical Chemistry Journal Aims and scope

Condensation of 3-hydroxy-5-aryl-1.2-dihydro-3H-1.4-benzodiazepin-2-ones with diphenylchlorophosphine was found to produce 3- or 5-diphenylphosphine oxides with high analgesic activity; ED50 values were (0.08 ± 0.02) – (0.97 ± 0.27) mg/kg.

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Authors and Affiliations

  1. A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences, 86 Lyustdorfskaya Road, 65080, Odessa, Ukraine

    V. I. Pavlovskii, S. A. Andronati, E. V. Voronenko, T. A. Kabanova & E. I. Khalimova

  2. A. N. Nesmeyanov Institute of Elementary Organic Compounds, Russian Academy of Sciences, 28 Vavilov Street, 119991, Moscow, Russia

    Yu. G. Gololobov, I. Yu. Krasnova & V. N. Khrustalev

Authors
  1. V. I. Pavlovskii
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  2. Yu. G. Gololobov
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  3. S. A. Andronati
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  4. E. V. Voronenko
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  5. T. A. Kabanova
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  6. E. I. Khalimova
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  7. I. Yu. Krasnova
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  8. V. N. Khrustalev
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Corresponding author

Correspondence to V. I. Pavlovskii.

Additional information

*For preliminary communication see: Yu. G. Gololobov, I. Yu. Krasnova, S. V. Barabanov, V. N. Khrustalev, S. A. Andronati, and V. I. Pavlovsky, Tetrahedron Let., 55, 4879 (2014); DOI:10.1016/j.tetlet.2014.07.010.

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 4, pp. 22 – 26, April, 2016.

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Pavlovskii, V.I., Gololobov, Y.G., Andronati, S.A. et al. Synthesis, Structure, and Analgesic Properties of Phosphorylated Dihydro-1,4-Benzodiazepin-2-Ones*. Pharm Chem J 50, 229–233 (2016). https://doi.org/10.1007/s11094-016-1428-8

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  • DOI: https://doi.org/10.1007/s11094-016-1428-8

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