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Synthesis and Analgesic Activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

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Pharmaceutical Chemistry Journal Aims and scope

A three-component reaction of acetoacetanilides with a mixture of an aromatic aldehyde and thiourea was used to synthesize previously unknown N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides, which had high analgesic activity and low acute toxicity.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, 2 Polevaya Street, 614990, Perm, Russia

    V. L. Gein, T. M. Zamaraeva, N. A. Buzmakova, B. Ya. Syropyatov & N. V. Alikina

Authors
  1. V. L. Gein
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  2. T. M. Zamaraeva
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  3. N. A. Buzmakova
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  4. B. Ya. Syropyatov
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  5. N. V. Alikina
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Correspondence to V. L. Gein.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 4, pp. 19 – 21, April, 2016.

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Gein, V.L., Zamaraeva, T.M., Buzmakova, N.A. et al. Synthesis and Analgesic Activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Pharm Chem J 50, 226–228 (2016). https://doi.org/10.1007/s11094-016-1427-9

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  • DOI: https://doi.org/10.1007/s11094-016-1427-9

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