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Synthesis and Antiviral Activity of Hydroxy-Substituted Benzaldehydes and Related Compounds

Pharmaceutical Chemistry Journal volume 50, pages 156–158 (2016)Cite this article

A series of hydroxy-substituted benzaldehydes and related compounds were synthesized and studied in cell culture against herpes simplex type I (HSV-1) and influenza A (H7N1) viruses. It was found that salicylaldehyde, 2,3-dihydroxybenzaldehyde, and gossypol could suppress HSV-1 replication. The structure–activity relationship of the series of hydroxylated benzaldehydes was analyzed.

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Authors and Affiliations

  1. Belarusian State University, Minsk, Belarus

    O. I. Shadyro, V. L. Sorokin, G. A. Ksendzova, O. V. Savinova, N. I. Pavlova & G. I. Polozov

  2. State Research and Practical Center for Epidemiology and Microbiology, Minsk, Belarus

    S. N. Samovich & E. I. Boreko

Authors
  1. O. I. Shadyro
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  2. V. L. Sorokin
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  3. G. A. Ksendzova
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  4. O. V. Savinova
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  5. S. N. Samovich
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  6. N. I. Pavlova
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  7. G. I. Polozov
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  8. E. I. Boreko
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 3, pp. 20 – 22, March, 2016.

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Shadyro, O.I., Sorokin, V.L., Ksendzova, G.A. et al. Synthesis and Antiviral Activity of Hydroxy-Substituted Benzaldehydes and Related Compounds. Pharm Chem J 50, 156–158 (2016). https://doi.org/10.1007/s11094-016-1414-1

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  • DOI: https://doi.org/10.1007/s11094-016-1414-1

Keywords

  • benzaldehyde
  • gossypol
  • ionol
  • antiviral activity
  • synthesis