Experimental Study of the Biocompatibility of Soft Tissues and a Finely Dispersed Sorbent Containing Silver

The physicochemical and biological properties of a new finely dispersed Si- and Al-containing sorbent are presented. Its modification using silver nanoclusters immobilized on the sorbent-particle surface is described. The parameters of the sorbent porous structure, its sorption activity, and the rate of silver release from the sorbent surface in contact with a liquid medium are determined. Both the sorbent matrix and the original silver-modified sorbent are well tolerated by experimental animals upon intramuscular administration and cause no changes in the behavior, weight, and appearance of the animals. Results from studies of the leukocyte, platelet, and red-blood-cell pools of peripheral blood also confirm that the sorbents are biocompatible with body tissues.

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Correspondence to T. V. Popova or T. G. Tolstikova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 3, pp. 16 – 19, March, 2016.

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Popova, T.V., Tolstikova, T.G., Letyagin, A.Y. et al. Experimental Study of the Biocompatibility of Soft Tissues and a Finely Dispersed Sorbent Containing Silver. Pharm Chem J 50, 152–155 (2016). https://doi.org/10.1007/s11094-016-1413-2

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Keywords

  • silver-containing sorbents
  • silver nanoclusters
  • biocompatibility