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Synthesis and Antibacterial Activity of 1-[2-(4-Aminosulfonylphenyl)Ethyl]-5-Aryl-4-Aroyl-3-Hydroxy-3-Pyrrolin-2-Ones

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Pharmaceutical Chemistry Journal Aims and scope

Reaction of the methyl esters of aroylpyruvic acids with mixtures of 4-(2-aminoethyl)benzenesulfonamide and an aromatic aldehyde was used to synthesize 1-[2-(4-aminosulfonylphenyl)ethyl]-5-aryl-4-aroyl-3-hydroxy- 3-pyrrolin-2-ones. The structures of these compounds were verified by IR and 1H NMR spectroscopy and mass spectrometry. Their antibacterial activity was studied.

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References

  1. V. L. Gein, T. F. Odegova, K. A. Tkachenko, et al., Khim.-Farm. Zh., 47(7), 31 – 33 (2013); Pharm. Chem. J., 47(7), 371 – 373 (2013).

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, 2 Polevaya Street, 614990, Perm, Russia

    V. L. Gein, O. V. Bobrovskaya, R. T. Valiev & T. F. Odegova

  2. Perm State National Research University, Perm, Russia

    G. A. Gartman

Authors
  1. V. L. Gein
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  2. O. V. Bobrovskaya
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  3. R. T. Valiev
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  4. T. F. Odegova
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  5. G. A. Gartman
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Corresponding author

Correspondence to V. L. Gein.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 9, pp. 32 – 34, September, 2015.

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Gein, V.L., Bobrovskaya, O.V., Valiev, R.T. et al. Synthesis and Antibacterial Activity of 1-[2-(4-Aminosulfonylphenyl)Ethyl]-5-Aryl-4-Aroyl-3-Hydroxy-3-Pyrrolin-2-Ones. Pharm Chem J 49, 602–604 (2015). https://doi.org/10.1007/s11094-015-1337-2

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  • DOI: https://doi.org/10.1007/s11094-015-1337-2

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