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Synthesis and Analgesic Activity of 3-Arylamino-1,2-Dihydro-3H-1,4-Benzodiazepin-2-Ones

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Abstract

Interaction of 3-chloro-5-aryl-1,2-dihydro-3H-1,4-benzodiazepines with aromatic amines was used to synthesize 3-arylamino-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with analgesic activity in the acetate acid writing test (ED50 0.007 – 3.2 mg).

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Authors and Affiliations

  1. A. V. Bogatskii Physicochemical Institute, Ukrainian National Academy of Sciences, 86 Lyustdorfskaya Road, 65080, Odessa, Ukraine

    V. I. Pavlovskii, I. Yu. Ushakov, T. A. Kabanova, E. I. Khalimova & S. A. Andronati

  2. Institute of Applied Physics, Moldova Academy of Sciences, 5 Akademicheskaya Street, MD2028, Kishinev, Republic of Moldova

    V. Kh. Kravtsov

Authors
  1. V. I. Pavlovskii
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  2. I. Yu. Ushakov
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  3. T. A. Kabanova
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  4. E. I. Khalimova
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  5. V. Kh. Kravtsov
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  6. S. A. Andronati
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Corresponding author

Correspondence to V. I. Pavlovskii.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 9, pp. 22 – 27, September, 2015.

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Pavlovskii, V.I., Ushakov, I.Y., Kabanova, T.A. et al. Synthesis and Analgesic Activity of 3-Arylamino-1,2-Dihydro-3H-1,4-Benzodiazepin-2-Ones. Pharm Chem J 49, 592–597 (2015). https://doi.org/10.1007/s11094-015-1335-4

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  • DOI: https://doi.org/10.1007/s11094-015-1335-4

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