Asolid dispersion of rutin based on polyvinylpyrrolidone had greater solubility than rutin substance, which is valuable for creating effective formulations based on this material. We describe here the preparation of tableted medicinal formulations of a solid dispersion of rutin prepared by direct pressing and moist granulation. A comparative analysis of the resulting granulates and tablets in terms of the main physical-technical characteristics is presented.
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This study was supported by the Ministry of Education in the framework of a State Contract 2014.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 7, pp. 47 – 51, July, 2015.
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Krasnyuk, I.I., Koval’skii, I.V., Nikulina, O.I. et al. Preparation and Investigation of Tabletted Medicinal Formulations of a Solid Dispersion of Rutin. Pharm Chem J 49, 481–485 (2015). https://doi.org/10.1007/s11094-015-1310-0
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DOI: https://doi.org/10.1007/s11094-015-1310-0