New (−)−Cytisine Derivatives with Nootropic Activity
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The mnestic and antihypoxic effects of new derivatives of the quinolizidine alkaloid (−)-cytisine on acquisition of a conditioned passive avoidance reflex (CPAR) were studied in rats; effects on normobaric (jar) hypoxia were studied in mice. Screening studies showed that the benzamide and the N-(12-methylcytidin-3-yl)-N′-phenylurea not only improved learning and memory, but also increased the resistance of the brain to hypoxia.
Keywords(−)-cytisine nootropic activity conditioned passive avoidance reflex antihypoxic properties
This study was supported by the Russian Foundation for Basic Research (Grant No. 12-03-00724-a) and the “Basic Sciences – Medicine” Basic Research Program of the Presidium of the Russian Academy of Sciences.
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