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Pharmaceutical Chemistry Journal

, Volume 49, Issue 5, pp 301–303 | Cite as

New (−)−Cytisine Derivatives with Nootropic Activity

  • N. S. MakaraEmail author
  • S. F. Gabdrakhmanova
  • T. A. Sapozhnikova
  • R. Yu. Khisamutdinova
  • A. V. Koval’skaya
  • I. P. Tsypysheva
  • F. S. Zarudii
Article

The mnestic and antihypoxic effects of new derivatives of the quinolizidine alkaloid (−)-cytisine on acquisition of a conditioned passive avoidance reflex (CPAR) were studied in rats; effects on normobaric (jar) hypoxia were studied in mice. Screening studies showed that the benzamide and the N-(12-methylcytidin-3-yl)-N′-phenylurea not only improved learning and memory, but also increased the resistance of the brain to hypoxia.

Keywords

(−)-cytisine nootropic activity conditioned passive avoidance reflex antihypoxic properties 

Notes

This study was supported by the Russian Foundation for Basic Research (Grant No. 12-03-00724-a) and the “Basic Sciences – Medicine” Basic Research Program of the Presidium of the Russian Academy of Sciences.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • N. S. Makara
    • 1
    Email author
  • S. F. Gabdrakhmanova
    • 1
  • T. A. Sapozhnikova
    • 1
  • R. Yu. Khisamutdinova
    • 1
  • A. V. Koval’skaya
    • 1
  • I. P. Tsypysheva
    • 1
  • F. S. Zarudii
    • 1
  1. 1.Institute of Organic ChemistryUfa Scientific Center, Russian Academy of SciencesUfaRussia

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