Modern concepts about the development of nano-sized drug carriers were reviewed using liposomes as an example. The history of liposome research including their structure, properties, interaction with molecules, and use as drug-delivery reservoirs was briefly discussed. Medical advantages of liposomal drugs were compared with those of traditional drugs. Strategies for increasing the efficiency of incorporating drugs into liposomes and stabilizing liposomal drugs and the mechanisms of their interactions with cells were discussed.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 2, pp. 41 – 49, February, 2015.
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Bushmakina, I.M., Martynova, M.A. & Knyazeva, E.V. XXI Century: How Our Notions About Liposomal Drugs Have Been Transformed. Pharm Chem J 49, 111–119 (2015). https://doi.org/10.1007/s11094-015-1232-x
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DOI: https://doi.org/10.1007/s11094-015-1232-x