Copolymers based on aliphatic diamines of various methylene chain lengths and guanidine hydrochloride were prepared by polycondensation in the melt. Antibacterial activity of water-soluble copolymers based on guanidine against conditionally pathogenic microorganisms Escherichia coli and Bacillus cereus was evaluated using diffusion in agar. Arelationship was found between the ratio of the number of hydrophobic methylene groups to the number of ionized guanidines and the antibacterial activity of the copolymers. Several samples showed high antimicrobial activity as compared with polyhexamethyleneguanidine hydrochloride (PHMGHC), which is widely used as a medical disinfectant.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 2, pp. 29 – 33, February, 2015.
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Grigor’eva, M.N., Stel’makh, S.A., Astakhova, S.A. et al. Synthesis of Polyalkylguanidine Hydrochloride Copolymers and Their Antibacterial Activity Against Conditionally Pathogenic Microorganisms Bacillus Cereus and Escherichia Coli . Pharm Chem J 49, 99–103 (2015). https://doi.org/10.1007/s11094-015-1230-z
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DOI: https://doi.org/10.1007/s11094-015-1230-z