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Synthesis and Antiradical and Antibacterial Activity of 4-(3′,4′-Dihydroxyphenyl)Thiazole Derivatives

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Pharmaceutical Chemistry Journal Aims and scope

A series of dihydroxyphenylthiazoles were synthesized via the reaction of 4-(chloroacetyl)catechol with thioamide derivatives. Their antiradical activity was studied using the reaction with the cation-radical 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Antimicrobial activity of the dihydroxyphenylthiazoles was studied against P. aeruginosa, C. albicans, S. epidermidis, and S. aureus. These compounds were found to belong to toxicity class 4.

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Correspondence to V. V. Odaryuk or I. D. Odaryuk.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 2, pp. 26 – 28, February, 2015.

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Odaryuk, V.V., Burakov, N.I., Kanibolotskaya, L.V. et al. Synthesis and Antiradical and Antibacterial Activity of 4-(3′,4′-Dihydroxyphenyl)Thiazole Derivatives. Pharm Chem J 49, 96–98 (2015). https://doi.org/10.1007/s11094-015-1229-5

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  • DOI: https://doi.org/10.1007/s11094-015-1229-5

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