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Synthesis and Antiradical and Antibacterial Activity of 4-(3′,4′-Dihydroxyphenyl)Thiazole Derivatives

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A series of dihydroxyphenylthiazoles were synthesized via the reaction of 4-(chloroacetyl)catechol with thioamide derivatives. Their antiradical activity was studied using the reaction with the cation-radical 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Antimicrobial activity of the dihydroxyphenylthiazoles was studied against P. aeruginosa, C. albicans, S. epidermidis, and S. aureus. These compounds were found to belong to toxicity class 4.

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  1. A. N. Shendrik, N. I. Burakov, A. L. Kanibolotskii, et al., Zh. Org. Farm. Khim., 9(4), 61 – 64 (2011).

    CAS  Google Scholar 

  2. K. A. Karpov, B. V. Pekarevskii, and V. M. Potekhin, Zh. Obshch. Khim., 71(9), 1567 – 1570 (2001).

    Google Scholar 

  3. Y. Lin, H. Fan, Y. Li, and X. Zhan, Adv. Mater., 24(22), 3087 – 3106 (2012).

    Article  CAS  PubMed  Google Scholar 

  4. M. V. Rubtsov and A. G. Baichikov, Synthetic Chemical Pharmaceutical Preparations [in Russian], Meditsina, Moscow, 1971, p. 53.

    Google Scholar 

  5. B. A. Kazanskii (ed.), Synthesis of Organic Compounds [in Russian], Coll. 4 [Russian translation], Inostrannaya Literatura, Moscow, 1953, p. 512.

  6. R. Re, N. Pellegrini, A. Proteggente, et al., Free Radical Biol. Med., 26(9/10), 1231 – 1237 (1999).

    Article  CAS  Google Scholar 

  7. L. G. Forni, V. O. Mora-Arellano, J. E. Packer, and R. L. Willson, J. Chem. Soc. Perkin Trans 2, No. 1, 1 – 6 (1986).

    Article  Google Scholar 

  8. F. S. Zarudii, G. Z. Gul_mitdinov, R. F. Zarudii, et al., Khim.-farm. Zh., 35(3), 42 – 48 (2001); Pharm. Chem. J., 35(3), 162 – 168 (2001).

  9. L. Z. Skala, S. V. Sidorenko, A. G. Nekhorosheva, et al., Practical Aspects of Modern Clinical Microbiology [in Russian], Triada, Tver, 2004.

  10. On Approval of Methodical Instructions “Definition of Microorganism Sensitivity to Antibacterial Drugs” [in Ukrainian], Ministry of Health of Ukraine Order No. 167, Apr. 5, 2007.

  11. OECD Guideline for the Testing of Chemicals No. 420: Acute Oral Toxicity – Fixed Dose Procedure, Organization for Economic Cooperation and Development, Paris, France, 2001.

  12. United Nations. Economic Commission for Europe. Globally harmonized system of classification and labelling of chemicals (GHS), Fourth revised edition, New York, USA, and Geneva, Switzerland, United Nations, 2011, p. 561;

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Correspondence to V. V. Odaryuk or I. D. Odaryuk.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 2, pp. 26 – 28, February, 2015.

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Odaryuk, V.V., Burakov, N.I., Kanibolotskaya, L.V. et al. Synthesis and Antiradical and Antibacterial Activity of 4-(3′,4′-Dihydroxyphenyl)Thiazole Derivatives. Pharm Chem J 49, 96–98 (2015).

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